Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.0 0.723 0.208 0.228
biological_process el 19 0.101 0.91 0.618 0.255
biological_process ka 19 0.0 0.698 0.201 0.233
biological_process rf 19 0.0 0.723 0.208 0.228
cellular_component ct 1 0.002 0.002 0.002 0.0
cellular_component el 1 0.573 0.573 0.573 0.0
cellular_component ka 1 0.005 0.005 0.005 0.0
cellular_component rf 1 0.002 0.002 0.002 0.0
disease ct 11 0.002 0.67 0.069 0.19
disease el 11 0.005 0.125 0.035 0.029
disease ka 11 0.001 0.717 0.071 0.204
disease rf 11 0.002 0.673 0.069 0.191
genetic_interaction ct 16 0.025 0.95 0.524 0.287
genetic_interaction el 16 0.027 1.0 0.549 0.265
genetic_interaction ka 16 1.0 1.0 1.0 0.0
genetic_interaction rf 16 0.025 1.0 0.554 0.297
molecular_function ct 3 0.001 0.75 0.378 0.306
molecular_function el 3 0.01 0.755 0.413 0.307
molecular_function ka 3 0.001 0.777 0.363 0.319
molecular_function rf 3 0.0 0.75 0.378 0.306
pathway ct 4 0.06 0.226 0.147 0.062
pathway el 4 0.003 0.169 0.098 0.064
pathway ka 4 0.003 1.0 0.537 0.466
pathway rf 4 0.042 0.176 0.104 0.05
phenotype ct 11 0.001 0.374 0.073 0.12
phenotype el 11 0.248 0.598 0.464 0.111
phenotype ka 11 0.001 0.431 0.085 0.131
phenotype rf 11 0.001 0.373 0.073 0.12
protein_interaction ct 20 0.0 0.668 0.076 0.162
protein_interaction el 20 0.0 0.715 0.073 0.171
protein_interaction ka 20 0.002 1.0 0.701 0.457
protein_interaction rf 20 0.0 0.659 0.074 0.159

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 20 0.0 0.651 0.148 0.194
integration_mean_by_presence el 20 0.001 0.53 0.099 0.14
integration_mean_by_presence ka 20 0.0 0.676 0.118 0.172
integration_mean_by_presence rf 20 0.001 0.351 0.057 0.098
mean ct 20 0.0 0.632 0.146 0.192
mean el 20 0.0 0.526 0.105 0.144
mean ka 20 0.0 0.681 0.105 0.17
mean rf 20 0.0 0.355 0.071 0.109

CDF plots of non integrated kernels

CDF plots of integrated kernels